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KMID : 0191120120270020141
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Journal of Korean Medical Science
2012 Volume.27 No. 2 p.141 ~ p.145
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Telomerase Activity and the Risk of Lung Cancer
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Jeon Hyo-Sung
Choi Jin-Eun
Jung Deuk-Kju
Choi Yi-Young
Kang Hyo-Gyoung
Lee Won-Kee
Yoo Seung-Soo
Lim Jeong-Ok
Park Jae-Yong
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Abstract
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Telomerase play a key role in the maintenance of telomere length and chromosome integrity. We have evaluated the association between telomerase activity and the risk of lung cancer in peripheral blood. Telomerase activity in peripheral blood mononuclear cells was measured by a PCR-designed telomeric repeat amplification protocol in 63 lung cancer patients and 190 healthy controls that were matched for age, gender, and smoking status. Telomerase activity was significantly lower in the lung cancer patients than in controls (mean ± standard deviation; 1.32 ± 1.65 vs 2.60 ± 3.09, P < 1 × 10-4). When telomerase activity was categorized into quartiles based on telomerase activity in the controls, the risk of lung cancer increased as telomerase activity reduced (Ptrend = 1 × 10-4). Moreover, when the subjects were categorized based on the median value of telomerase activity, subjects with low telomerase activity were at a significantly increased risk of lung cancer compared to subjects with high telomerase activity (adjusted odds ratio = 3.05, 95% confidence interval = 1.60-5.82, P = 7 × 10-4). These findings suggest that telomerase activity may affect telomere maintenance, thereby contributing to susceptibility to lung cancer.
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KEYWORD
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Lung Cancer, Telomerase Activity, Susceptibility
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